In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues.

نویسندگان

  • Diana Matthes
  • Lennart Richter
  • Jane Müller
  • Alexander Denisiuk
  • Sven C Feifel
  • Yuquan Xu
  • Patricia Espinosa-Artiles
  • Roderich D Süssmuth
  • István Molnár
چکیده

New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.

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عنوان ژورنال:
  • Chemical communications

دوره 48 45  شماره 

صفحات  -

تاریخ انتشار 2012